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Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds
Yu-Lun Qian1, Peng-Ju Xia, Jun Li
1College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China. hyangchem@csu.edu.cn xianghaoyue@csu.edu.cn.
Organic & Biomolecular Chemistry
|October 13, 2017
Abstract:
A diversity-driven three-component 1,3-dipolar cycloaddition of isatins, amino acids and isatin-derived ketimines was developed to facilely assemble dispirooxindole-imidazolidine skeletons bearing vicinal quaternary carbon centers. This protocol features additive-free, minimal solvent usage (0.1 mL DMSO/0.2 mmol scale), wide substrate scope (34 examples), mild reaction conditions (room temperature) and high chemical yield (up to 99%).