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Vitamin D Deficiency in Acute Coronary Syndrome - Clinically Relevant or Incidental Finding?

Marijana Knežević Praveček1, Željka Vuković-Arar2, Blaženka Miškić3

  • 1Department of Cardiology, Dr. Josip Benčević General Hospital, School of Medicine, Josip Juraj Strossmayer University, Osijek, Croatia.

Central European Journal of Public Health
|October 13, 2017
PubMed

Insights

Patients with acute coronary syndrome (ACS) have lower vitamin D levels. While low vitamin D is common in ACS, it did not predict major adverse cardiac events over three years.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is linked to cardiovascular disease.
  • Acute coronary syndrome (ACS) represents a critical manifestation of cardiovascular disease.

Purpose of the Study:

  • To measure serum 25-hydroxyvitamin D (25(OH)D) levels in ACS patients.
  • To evaluate the prognostic significance of vitamin D levels in ACS patients over a 3-year follow-up period.

Main Methods:

  • Included 60 ACS patients and 60 controls.
  • Measured serum 25(OH)D levels via standard laboratory testing.
  • ACS patients underwent coronarography and were followed for major adverse cardiac events (MACE) for 36 months.

Main Results:

  • ACS patients exhibited significantly lower mean 25(OH)D levels (35.19 nmol/L) compared to controls (58.08 nmol/L).
  • Diabetic ACS patients had the lowest mean 25(OH)D levels (30.45 nmol/L).
  • Low serum 25(OH)D in the acute phase of ACS did not significantly correlate with MACE during the 36-month follow-up.

Conclusions:

  • Patients with ACS demonstrate lower serum vitamin D concentrations, particularly those with diabetes.
  • Serum vitamin D levels were not found to be a useful prognostic biomarker for ACS patients in this 3-year study.
Abstract

Keywords:
25-hydroxyvitamin Dacute coronary syndromecoronary angiographydiabetesvitamin D deficiency

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