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Related Experiment Video

Updated: Feb 21, 2026

Microvascular Embolism Mouse Model for In Vivo Two-photon Microscopy Using Fluorescent Polystyrene Microspheres

Microvascular Embolism Mouse Model for In Vivo Two-photon Microscopy Using Fluorescent Polystyrene Microspheres

Published on: November 21, 2025

Visual impairment by multiple vascular embolization with hydroxyapatite particles.

Yayoi Marumo¹, Miki Hiraoka¹, Masato Hashimoto²

¹a Department of Ophthalmology, School of Medicine , Sapporo Medical University , Sapporo , Japan.

Orbit (Amsterdam, Netherlands)

|October 13, 2017

Summary

Hydroxyapatite filler injections can cause serious ocular complications, including vision loss and nerve damage, due to vascular emboli. Prompt diagnosis and management are crucial for mitigating severe outcomes.

Area of Science:

Ophthalmology
Dermatology
Plastic Surgery

Background:

Cosmetic filler injections, particularly hydroxyapatite fillers, are increasingly popular for aesthetic enhancements.

Keywords:

Hydroxyapatite filler injection ocular impairment skin necrosis vascular occlusion

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Complications from these procedures, including vascular events, are a growing concern in clinical practice.