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Anion Relay Chemistry: Development of an Effective Diastereoselective [3+2] Annulation Tactic Exploiting an
1Department of Chemistry, University of Pennsylvania, 231 S. 34th street, Philadelphia, PA, 19104, USA.
Angewandte Chemie (International Ed. in English)
|October 13, 2017
Abstract:
An effective [3+2] annulation tactic for the construction of diverse bicyclic compounds possessing highly functionalized cyclopentane rings has been developed employing soft ketone enolates as the initial nucleophile for anion relay chemistry (ARC). The protocol entails a highly diastereoselective aldol/Brook rearrangement/cyclization cascade.