Related Experiment Videos
IFN-Lambda: The Key to Norovirus's Secret Hideaway
Sonja M Best1, Shelly J Robertson1
1Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, 903 South Fourth Street, Hamilton, MT 59840, USA.
Cell Host & Microbe
|October 13, 2017
Abstract:
The cellular tropism of noroviruses in immune-competent hosts remains enigmatic. In recent studies in Cell Host & Microbe and Immunity, Lee et al. (2017) and Tomov et al. (2017) determine that norovirus innate immune evasion enables infection of intestinal epithelial cells, escape from adaptive immunity, virus persistence, and shedding.