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Related Experiment Videos

Tablet coating by injection molding technology - Optimization of coating formulation attributes and coating process

Parind M Desai1, Vibha Puri2, David Brancazio3

  • 1Novartis-MIT Center of Continuous Manufacturing, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Product & Process Engineering Department, GlaxoSmithKline, King of Prussia 19406, PA, USA.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|October 13, 2017
PubMed
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A novel solvent-free injection molding (IM) coating technology was developed for continuous manufacturing. This method created stable, crack-free tablet coatings with improved drug release profiles.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Continuous manufacturing offers advantages for pharmaceutical production.
  • Developing efficient and scalable coating technologies is crucial for drug delivery systems.

Purpose of the Study:

  • To develop and evaluate a solvent-free injection molding (IM) coating technology for tablets.
  • To assess the suitability of IM coating for continuous manufacturing processes.
  • To identify optimal coating formulations with desirable mechanical and melt flow properties.

Main Methods:

  • Coating formulations were prepared using hot-melt extrusion.
  • Formulations were screened for mechanical properties using stress-strain analysis.
  • Tablets were coated using a vertical injection molding unit.
Keywords:
CoatingDissolutionHot-melt extrusionInjection moldingMelt flowStress-strain analysis

Related Experiment Videos

  • Process parameters and environmental conditions (humidity) were investigated.

    • Main Results:

    • Three formulations (hydroxypropyl pea starch, PEO 1,000,000, Opadry) exhibited favorable mechanical and melt flow properties.
    • IM coating performance was sensitive to process parameters and room humidity for certain formulations.
    • Coated tablets showed increased dissolution times (10-35 min) and remained stable for 8 weeks.
    • Unsuitable mechanical properties were observed for Eudrajit E PO and Kollicoat IR formulations.

    Conclusions:

    • Solvent-free IM coating is a viable technology for continuous tablet manufacturing.
    • Optimized formulations provide stable and effective tablet coatings.
    • This technology enhances drug release control and tablet stability.