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Related Experiment Videos

Overtraining modifies spatial memory susceptibility to corticosterone administration.

Alejandro Múnera1, Mayerli A Prado-Rivera2, D Carolina Cárdenas-Poveda2

  • 1Physiological Sciences Department, School of Medicine, Universidad Nacional de Colombia, Colombia; Behavioural Neurophysiology Laboratory, Universidad Nacional de Colombia, Colombia.

Neurobiology of Learning and Memory
|October 13, 2017
PubMed
Summary
This summary is machine-generated.

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Overtraining enhances spatial memory retrieval but alters extinction retention. Corticosterone affects trained animals more than overtrained ones, suggesting overtraining modifies memory

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Cognitive Psychology

Background:

  • Overtraining and glucocorticoids impact spatial memory phases.
  • The interaction between overtraining and glucocorticoids on spatial memory retrieval and extinction is not well understood.

Purpose of the Study:

  • To investigate the combined effects of overtraining and corticosterone on spatial memory retrieval and extinction in rats.
  • To determine how overtraining influences the susceptibility of spatial memory to corticosterone during retrieval and extinction.

Main Methods:

  • Adult male Wistar rats underwent one or two days of Barnes maze training (overtraining).
  • Rats received vehicle or corticosterone injections before memory retrieval and extinction trials.
  • Spatial memory retrieval, extinction acquisition, and extinction retention were assessed.
Keywords:
CorticosteroneExtinctionOvertrainingRatSpatial memory

Related Experiment Videos

Main Results:

  • Overtraining improved spatial memory retrieval compared to single-session training.
  • Corticosterone impaired retrieval in trained but not overtrained rats.
  • Overtrained rats showed faster extinction acquisition but experienced spontaneous recovery, unlike trained rats.
  • Corticosterone's effects on extinction retention differed between trained and overtrained groups.

Conclusions:

  • Overtraining alters the impact of corticosterone on spatial memory retrieval and extinction.
  • Spatial memory trace susceptibility to corticosterone is modified by training intensity.
  • These findings highlight the complex interplay between stress, learning intensity, and memory consolidation.