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Angiogenic Growth Factors for Coronary Artery Disease: Current Status and Prospects

Ming Guo1,2, Jun-He Shi3, Pei-Li Wang1,2

  • 11 China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

Journal of Cardiovascular Pharmacology and Therapeutics
|October 14, 2017
PubMed

Insights

Therapeutic angiogenesis shows promise for ischemic coronary artery disease (CAD) patients ineligible for revascularization. While preclinical studies are encouraging, clinical trial evidence for efficacy remains limited, necessitating further investigation.

Area of Science:

  • Cardiovascular Medicine
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Coronary artery disease (CAD) remains a leading cause of mortality.
  • Revascularization options like bypass grafting and angioplasty are not suitable for all ischemic CAD patients.
  • Cardiac angiogenesis, the formation of new blood vessels, is a natural response to ischemia and a potential therapeutic target.

Purpose of the Study:

  • To review the physiological mechanisms of cardiac angiogenesis.
  • To discuss the properties of angiogenic growth factors and their delivery systems.
  • To analyze the current evidence from clinical and preclinical studies on therapeutic angiogenesis for CAD.

Main Methods:

  • Literature review of preclinical and clinical studies on cardiac angiogenesis.
  • Analysis of the characteristics of angiogenic growth factors.
  • Examination of various delivery systems for therapeutic angiogenesis.

Main Results:

  • Preclinical studies demonstrate significant potential for therapeutic angiogenesis in ischemic CAD.
  • Clinical trials have thus far provided limited evidence regarding the efficacy of therapeutic angiogenesis.
  • The physiological process, growth factors, and delivery systems are key considerations for future strategies.

Conclusions:

  • Therapeutic angiogenesis offers a potential alternative for CAD patients unsuitable for traditional revascularization.
  • Further research and well-designed clinical trials are crucial to establish the efficacy and safety of therapeutic angiogenesis.
  • A deeper understanding of angiogenic mechanisms and optimized delivery is needed to translate preclinical promise into clinical success.

Keywords:
angiogenesisangiogenic growth factorscoronary artery diseasetherapeutic angiogenesis

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