Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Arterial Thrombus Stability: Does It Matter and Can We Detect It?

Diana A Gorog1, Zahi A Fayad2, Valentin Fuster3

  • 1National Heart & Lung Institute, Imperial College, London, United Kingdom; Postgraduate Medical School, University of Hertfordshire, Hertfordshire, United Kingdom.

Journal of the American College of Cardiology
|October 14, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thrombus formation, endogenous fibrinolysis and atrial fibrillation states in patients with ischaemic stroke: An assessment using global thrombosis test profiles.

Thrombosis research·2026
Same author

Antithrombotic therapy for secondary prevention in patients with acute coronary syndromes treated with percutaneous coronary intervention: options for personalization to reduce bleeding or ischaemic risks. A Clinical Consensus Statement of the ESC Working Group on Thrombosis, the Association for Acute CardioVascular Care of the ESC, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the ESC Working Group on Cardiovascular Pharmacology A Clinical Consensus Statement of the ESC Working Group on Thrombosis, the Association for Acute CardioVascular Care of the ESC, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the ESC Working Group on Cardiovascular Pharmacology.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2026
Same author

Coagulation at the crossroads: Cancer, congenital disease, and critical illness.

Journal of thrombosis and thrombolysis·2026
Same author

Clopidogrel Vs Aspirin Monotherapy for Secondary Prevention After Percutaneous Coronary Intervention: A Nationwide Cohort Study.

JACC. Asia·2026
Same author

Oral Anticoagulation With or Without Antiplatelet Therapy in Chronic Coronary Syndrome: A Meta-Analysis of Randomized Trials.

JACC. Cardiovascular interventions·2026
Same author

Reply: Generative AI-Powered Virtual Assistant for Guideline-Directed Medical Therapy Optimization.

JACC. Advances·2026

Thrombus stability is key in preventing heart attacks. New methods to assess and promote clot breakdown could reduce heart damage by targeting clot instability.

Area of Science:

  • Cardiovascular Science
  • Hemostasis and Thrombosis
  • Biomedical Imaging

Background:

  • Spontaneous lysis of coronary thrombi is a protective mechanism against myocardial infarction.
  • Thrombus stability significantly impacts clinical outcomes in acute coronary events.
  • Impaired fibrinolytic activity is linked to acute coronary syndromes, yet factors affecting thrombus stability are understudied.

Purpose of the Study:

  • To review the importance of thrombus stability in arterial thrombosis.
  • To highlight the need for physiologically relevant assays to assess spontaneous thrombus disintegration.
  • To describe novel in vivo imaging techniques for characterizing thrombosis.

Main Methods:

  • Review of experimental evidence on thrombus stability.
Keywords:
fibrinolysisimagingplatelet function testplateletsstabilitythrombus

Related Experiment Videos

  • Discussion of in vitro techniques for assessing thrombus stability.
  • Description of novel in vivo imaging modalities for thrombosis characterization.

    • Main Results:

    • Thrombus stability is a critical determinant of clinical outcome in arterial thrombosis.
    • Physiologically relevant assays are needed to evaluate spontaneous fibrinolysis of platelet-rich thrombi under arterial flow.
    • Novel imaging techniques can characterize thrombosis in vivo.

    Conclusions:

    • Understanding and modulating thrombus stability is crucial for managing acute coronary events.
    • Development of advanced in vitro and in vivo methods is essential for assessing thrombus behavior.
    • Tailoring pharmacotherapy to enhance thrombus instability may reduce infarct size.