Related Experiment Video

Updated: Apr 25, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
08:32

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

Published on: March 16, 2017

13.7K

Genetics of NO Deficiency

Kirsten Leineweber1, Sven Moosmang2, Dan Paulson3

  • 1Bayer AG, Disease Genomics, Wuppertal, Germany.

The American Journal of Cardiology
|October 14, 2017
PubMed

Insights

Nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway gene variants can lead to NO-cGMP deficiency, impacting cardiovascular disease risk. This review explores the role of NO-cGMP deficiency in cardiovascular health.

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology
  • Genetics

Background:

  • The nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway is crucial for cardiovascular homeostasis.
  • Genetic variations impacting this pathway can lead to NO-cGMP deficiency, potentially influencing cardiovascular disease (CVD).
  • NO-cGMP deficiency arises from various mechanisms, including issues with nitric oxide synthase (NOS) and altered cGMP metabolism.

Purpose of the Study:

  • To review the evidence linking NO-cGMP pathway deficiency to cardiovascular disease.
  • To discuss the role of genetic variants, polymorphisms, haplotypes, and racial disparities in NO-cGMP deficiency and CVD.
  • To examine key components of the NO-cGMP pathway implicated in cardiovascular health.

Main Methods:

  • Literature review of genetic association studies.
  • Analysis of evidence linking NO-cGMP pathway dysfunction to cardiovascular outcomes.
  • Discussion of specific NO-cGMP pathway components and their roles.

Main Results:

  • Genetic variants in NO-cGMP pathway genes are associated with cardiovascular disease prevalence and progression.
  • Multiple factors contribute to NO-cGMP deficiency, affecting nitric oxide bioavailability and cGMP signaling.
  • Evidence supports a significant role for NO-cGMP pathway dysfunction in various cardiovascular conditions.

Conclusions:

  • NO-cGMP pathway deficiency, influenced by genetic factors, is a significant contributor to cardiovascular disease.
  • Understanding these genetic links and pathway components is vital for cardiovascular research and potential therapeutic strategies.
  • Further investigation into genetic disparities and NO-cGMP pathway modulation is warranted for CVD prevention and treatment.

More Related Videos

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements07:19

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements

Published on: July 29, 2021

2.5K
Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

4.4K

Related Concept Videos

Overview of Nitrogen Metabolism01:20

Overview of Nitrogen Metabolism

Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of  ammonia, ammonium ions, nitrate, nitrite, or  nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
8.5K
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.2K
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.5K
Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
1.9K
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K