Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyurethane foam/nano hydroxyapatite composite as a suitable scaffold for bone tissue regeneration.

M Meskinfam1, S Bertoldi2, N Albanese3

  • 1Department of Chemistry, Materials and Chemical Engineering "G. Natta" Politecnico di Milano, Milano, Italy; Lahijan Branch, Islamic Azad University, Lahijan, Iran.

Materials Science & Engineering. C, Materials for Biological Applications
|October 14, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of the Soft-Drop Jet Mass in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2018
Same author

Measurement of jet fragmentation in Pb+Pb and

The European physical journal. C, Particles and fields·2018
Same author

Precision measurement and interpretation of inclusive

The European physical journal. C, Particles and fields·2018
Same author

Search for new phenomena using the invariant mass distribution of same-flavour opposite-sign dilepton pairs in events with missing transverse momentum in

The European physical journal. C, Particles and fields·2018
Same author

Search for Low-Mass Dijet Resonances Using Trigger-Level Jets with the ATLAS Detector in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2018
Same author

Search for the Decay of the Higgs Boson to Charm Quarks with the ATLAS Experiment.

Physical review letters·2018

Biomineralized polyurethane foams offer a promising alternative for bone regeneration. These scaffolds enhance cell interaction and mechanical strength, supporting tissue repair effectively.

Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Orthopedic Research

Background:

  • Bone tissue regeneration often relies on grafts, which have limitations.
  • Biomineralized scaffolds present a viable alternative for bone defect repair.
  • Polyurethane (PU) foams are explored for their potential in bone regeneration.

Purpose of the Study:

  • To investigate biomineralized polyurethane foams as scaffolds for bone tissue regeneration.
  • To evaluate the morphological, chemico-physical, and mechanical properties of these scaffolds.
  • To assess the in vitro interaction of the scaffolds with rat Bone Marrow Mesenchymal Stem Cells (BMSCs).

Main Methods:

  • PU foams underwent a two-step surface activation biomineralization process for 1-4 weeks.
Keywords:
BiomineralizationBoneNano hydroxy apatitePolyurethanePorous scaffoldTissue engineering

Related Experiment Videos

  • Scaffolds were analyzed for morphology, pore size, and mechanical properties.
  • Fourier Transform Infrared spectroscopy and X-ray diffraction confirmed nano hydroxyapatite formation.
  • In vitro cytocompatibility assays with BMSCs were performed.

    • Main Results:

    • Biomineralized PU foams exhibited homogenous morphology and consistent pore size (average Ø=407μm).
    • Formation of bone-like nano hydroxyapatite on the PU surface was confirmed.
    • Biomineralization significantly enhanced the mechanical properties of the PU scaffolds.
    • Improved cell attachment and proliferation of BMSCs were observed on the biomineralized scaffolds.

    Conclusions:

    • Biomineralized PU foams demonstrate suitable characteristics for bone tissue regeneration scaffolds.
    • The enhanced mechanical properties and cytocompatibility make them a promising alternative to traditional bone grafts.
    • These scaffolds provide an appropriate surface for cell interactions crucial for tissue repair.