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One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles
Published on: September 17, 2013
Comb-shaped, temperature-tunable and water-soluble porphyrin-based thermoresponsive copolymer for enhanced
Changling Liu1, Yanhui Li2, Bo Gao2
1School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China; School of Materials science and Engineering, Jilin Institute of Chemical Technology, Jilin City 132022, China.
Abstract:
A novel comb-shaped porphyrin end-functionalized poly(N-isopropylacrylamide)-b-poly[oligo (ethylene glycol methyl ether methacrylate)] (Por-PNIPAM-b-POEGMA) was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Due to the incorporation of hydrophilic POEGMA contents, the copolymer shows the lower critical solution temperatures (LCST) of 37-41.8°C higher than PNIPAM. Moreover, this copolymer showed efficient singlet oxygen under light irradiation at 650nm, and the productivity of singlet oxygen was 0.59, which could be used for photodynamic therapy. In addition, the in vitro study indicated that this copolymer showed no significant dark cytotoxicity, while showed apparent photo-toxicity toward HeLa cancer cells under red light irradiation at 650nm. MTT results indicated that this copolymer with appropriate LCST could be accumulated on locally tumor tissues and killing of cancer cells (Hela), which may be a promising photosensitizer in photodynamic therapy for cancer treatment.
