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Updated: Feb 21, 2026
08:51
Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
Published on: May 10, 2019
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A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
Michael R Bowl1, Michelle M Simon1, Neil J Ingham2,3
1Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
Nature Communications
|October 14, 2017
Summary
Researchers screened 3006 mouse models to uncover new genes linked to hearing loss. This study identified 52 novel candidate genes, expanding our understanding of the genetic basis of auditory dysfunction.
Area of Science:
- Genetics
- Auditory Science
- Molecular Biology
Background:
- The genetic basis of hearing impairment is incompletely understood, despite over 100 known genes for non-syndromic hearing loss.
- Human auditory dysfunction is associated with over 150 non-syndromic loci and more than 400 genetic syndromes.
Purpose of the Study:
- To systematically screen a large cohort of mouse knockout strains for auditory defects.
- To identify novel genes involved in auditory function and hearing loss.
Main Methods:
- A large-scale hearing loss screen was conducted on 3006 mouse knockout strains.
- Utilized the International Mouse Phenotyping Consortium's resources for systematic genetic screening.
Main Results:
- Identified a total of 67 candidate genes associated with hearing loss.
- Discovered 52 novel candidate genes, significantly expanding the known genetic landscape of auditory function.
- Confirmed known hearing loss genes within the screened cohort.
Conclusions:
- The genetic landscape underlying auditory function is vast and largely unexplored.
- This study provides a significant expansion of candidate genes for genetic hearing loss, paving the way for future research into auditory development and dysfunction.
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