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Related Experiment Video

Updated: Feb 21, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
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Three-Dimensional SERS Substrates Formed with Plasmonic Core-Satellite Nanostructures.

Li-An Wu1, Wei-En Li1, Ding-Zheng Lin2

  • 1Institute of Biophotonics, National Yang-Ming University, Taipei, 112, Taiwan.

Scientific Reports
|October 14, 2017
PubMed
Summary

We developed novel three-dimensional surface-enhanced Raman spectroscopy (SERS) substrates using DNA-assisted assembly of gold nanoparticles. These substrates offer enhanced sensitivity and reproducibility for detecting molecules like melamine.

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Area of Science:

  • Plasmonics
  • Nanotechnology
  • Spectroscopy

Background:

  • Surface-enhanced Raman spectroscopy (SERS) requires optimized nanostructures to generate electromagnetic "hot spots" for sensitive molecular detection.
  • Existing SERS substrates often face challenges with reproducibility and sensitivity due to nanostructure distribution and spacing.

Purpose of the Study:

  • To develop three-dimensional (3D) SERS substrates with densely packed plasmonic nanostructures for enhanced sensing.
  • To optimize the synthesis and assembly of core-satellite nanostructures for improved SERS performance.
  • To demonstrate the sensitive and reproducible detection of analytes using the novel 3D SERS substrates.

Main Methods:

  • Synthesized gold nanoparticles (AuNPs) using a DNA-assisted assembly method.
  • Created core-satellite nanostructures by immobilizing AuNPs onto polymer beads, optimizing immobilization parameters (salt concentration, AuNP:bead ratio).
  • Applied a silver (Ag) shell to AuNPs to reduce interparticle distance and enhance electromagnetic coupling.
  • Fabricated 3D SERS substrates by drying nanostructure-containing droplets on hydrophobic surfaces to achieve dense packing.

Main Results:

  • Achieved high-density immobilization of AuNPs on polymer beads, forming effective core-satellite structures.
  • Optimized Ag shell thickness on AuNPs to maximize SERS signal enhancement.
  • Demonstrated significantly stronger and more reproducible SERS signals from the accumulated 3D nanostructures compared to dispersed ones.
  • Successfully detected melamine and sodium thiocyanate (NaSCN) with high sensitivity using the developed 3D SERS substrates.

Conclusions:

  • The developed DNA-assisted assembly method enables the creation of 3D SERS substrates with densely packed plasmonic nanostructures.
  • These 3D SERS substrates provide superior sensitivity and reproducibility due to optimized electromagnetic hot spots and controlled nanogap formation.
  • The novel substrates show great potential for sensitive and reliable detection of various analytes.