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Poorly controlled postoperative pain: prevalence, consequences, and prevention.

Tong J Gan1

  • 1Stony Brook University, Stony Brook, NY, USA.

Journal of Pain Research
|October 14, 2017
PubMed
Summary
This summary is machine-generated.

Poorly managed postoperative pain affects over 80% of patients. Novel μ-receptor modulators like oliceridine offer improved pain relief with fewer adverse events than traditional opioids.

Keywords:
acute painanalgesicschronic painopioidsurgical procedures

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Area of Science:

  • Anesthesiology
  • Pain Management
  • Pharmacology

Background:

  • Postoperative pain is a significant clinical challenge, inadequately managed in over 80% of US patients.
  • Poorly controlled pain leads to increased morbidity, delayed recovery, and chronic pain development.
  • Current treatments, including conventional opioids, have limitations due to adverse events.

Purpose of the Study:

  • To review the clinical issue of poorly controlled postoperative pain.
  • To explore therapeutic approaches for effective acute pain management.
  • To highlight novel analgesics with improved safety profiles.

Main Methods:

  • Review of clinical literature on postoperative pain management.
  • Analysis of therapeutic strategies, including local anesthetics, nonopioid analgesics, and novel opioids.
  • Evaluation of oliceridine (TRV130) clinical study data.

Main Results:

  • Conventional opioids are standard but limited by adverse events.
  • Novel μ-receptor G-protein pathway-selective modulators show promise.
  • Oliceridine demonstrated rapid postoperative analgesia with reduced adverse events compared to morphine.

Conclusions:

  • More effective perioperative analgesic strategies are needed to prevent persistent pain.
  • Novel opioid modulators offer a wider therapeutic window.
  • Oliceridine represents a promising advancement in managing acute postoperative pain.