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Updated: Jul 27, 2026
07:22
Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency
Published on: January 15, 2017
Prolonged Delayed Renal Graft Function Secondary to Venous Hypertension.
Suraj Mishra1, Gaurav Gupta1, I Moinuddin1
1Division of Nephrology, Virginia Commonwealth University, Richmond, VA.
Transplantation Direct
|October 14, 2017
Summary
A highly sensitized woman experienced prolonged delayed graft function after a second kidney transplant due to inferior vena cava thrombosis. Prompt intervention improved her renal function, highlighting a rare cause of transplant complications.
Area of Science:
- Nephrology
- Transplantation Immunology
- Vascular Surgery
Background:
- A highly sensitized patient with a history of thromboses underwent a second kidney transplant.
- The patient had a history of frequent thromboses of her left femoral arteriovenous graft (AVG) and was on warfarin.
Purpose of the Study:
- To report a rare case of prolonged delayed graft function (DGF) in a kidney transplant recipient.
- To investigate the cause of persistent DGF despite successful treatment of antibody-mediated rejection.
Main Methods:
- A flow cytometric positive crossmatch kidney transplant was performed.
- Computed tomography (CT) scan and venography were used to diagnose the cause of DGF.
- Interventions included graft declotting, iliac venoplasty, and inferior vena cava (IVC) stenting.
Main Results:
- The patient experienced prolonged DGF for 9 months post-transplant.
- Venography revealed chronic thrombus in the IVC with significant venous hypertension.
- Following IVC stenting and graft declotting, renal function improved significantly.
Conclusions:
- Inferior vena cava (IVC) thrombosis can be a rare cause of prolonged DGF in kidney transplant recipients.
- Venous hypertension secondary to IVC thrombosis should be considered in cases of unexplained DGF.
- Successful management of IVC thrombosis led to improved allograft function.
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