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Related Experiment Videos

Microsomal enzyme induction by permethrin in rats.

A Anadon1, M J Diez, M Sierra

  • 1Departamento de Toxicologia, Facultad de Veterinaria, Universidad de Leon, Spain.

Veterinary and Human Toxicology
|August 1, 1988
PubMed
Summary
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The synthetic pyrethroid, permethrin, alters liver drug metabolism in rats. Higher doses of permethrin significantly impact antipyrine kinetics and increase gamma-glutamyl transpeptidase (gamma-GTP) activity, indicating enzyme induction.

Area of Science:

  • Toxicology
  • Pharmacology
  • Biochemistry

Background:

  • Hepatic microsomal drug-metabolizing enzymes are crucial for xenobiotic detoxification.
  • Synthetic pyrethroids, like permethrin, are widely used insecticides with potential toxicological implications.
  • Understanding permethrin's effects on liver function is vital for assessing its safety.

Purpose of the Study:

  • To investigate the impact of permethrin on hepatic microsomal drug-metabolizing function in rats.
  • To evaluate the dose-dependent effects of permethrin on plasma antipyrine pharmacokinetics.
  • To assess the influence of permethrin on gamma-glutamyl transpeptidase (gamma-GTP) activity.

Main Methods:

  • Rats were administered varying doses of permethrin (90 mg/kg/day and 190 mg/kg/day) for 3 days.

Related Experiment Videos

  • Plasma antipyrine kinetics, including half-life, area under the curve, volume of distribution, and clearance, were analyzed.
  • Gamma-glutamyl transpeptidase (gamma-GTP) activity in liver microsomes was measured.

    • Main Results:

    • Low-dose permethrin (90 mg/kg/day) did not significantly alter antipyrine half-life or area under the curve but increased clearance and volume of distribution.
    • High-dose permethrin (190 mg/kg/day) significantly decreased antipyrine half-life and area under the curve, while increasing clearance and volume of distribution.
    • Permethrin administration led to a significant increase in gamma-GTP activity within 14-21 days, dose-dependently.

    Conclusions:

    • Permethrin exhibits a dose-dependent enzyme-inducing effect on hepatic drug metabolism in rats.
    • The observed alterations in antipyrine kinetics suggest accelerated drug metabolism following permethrin exposure.
    • Increased gamma-GTP activity further supports permethrin's role as an inducer of hepatic microsomal enzymes.