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Related Experiment Videos

Comparative Oral Absorption of Curcumin in a Natural Turmeric Matrix with Two Other Curcumin Formulations: An

Sreeraj Gopi1, Joby Jacob1, Karthik Varma1

  • 1R&D Centre, Aurea Biolabs (P) Ltd, Cochin, India.

Phytotherapy Research : PTR
|October 14, 2017
PubMed
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A natural turmeric matrix formulation significantly enhances curcuminoid bioavailability compared to other commercial products. This natural curcumin formulation shows superior absorption in healthy adults.

Area of Science:

  • Pharmacology and Pharmacokinetics
  • Natural Product Chemistry
  • Human Health and Nutrition

Background:

  • Curcuminoids, the active compounds in turmeric, have limited bioavailability, hindering their therapeutic applications.
  • Developing enhanced bioavailability formulations is crucial for realizing the health benefits of curcuminoids.
  • Existing commercial formulations, such as those with volatile oil or phospholipids, aim to improve curcumin absorption.

Purpose of the Study:

  • To evaluate the bioavailability of a completely natural turmeric matrix formulation (CNTMF).
  • To compare the bioavailability of CNTMF against two commercial curcumin formulations (volatile oil and phospholipid).
  • To assess curcuminoid absorption in healthy adult males under fasting conditions.

Main Methods:

Keywords:
blood plasma absorptionclinical trialcompletely natural turmeric matrixcurcumin formulationsphospholipidturmeric oil

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  • A randomized controlled study involving 45 healthy adult males (15 per group).
  • Administration of a single 500-mg oral dose of each formulation in capsule form.
  • Analysis of plasma curcuminoid levels using liquid chromatography-mass spectrometry up to 24 hours post-administration.

    • Main Results:

    • The CNTMF demonstrated a significantly higher peak plasma concentration (Cmax) of curcuminoids (170.14 ng/mL) compared to the volatile oil (47.54 ng/mL) and phospholipid (69.63 ng/mL) formulations.
    • The time to reach peak plasma concentration (Tmax) was 4 hours for CNTMF, versus 3 hours for volatile oil and 2.25 hours for phospholipid formulations.
    • Total curcuminoid absorption was 6 times greater for CNTMF than the volatile oil formulation and 5 times greater than the phospholipid formulation.

    Conclusions:

    • Curcumin formulated within a natural turmeric matrix exhibits superior oral bioavailability in humans compared to commercial volatile oil and phospholipid formulations.
    • The CNTMF represents a promising approach to overcoming the bioavailability limitations of curcuminoids.
    • Further research may explore the long-term efficacy and safety of this enhanced natural turmeric formulation.