Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

99.2K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
99.2K
RNA-seq03:21

RNA-seq

12.2K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
12.2K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.8K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

27
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
27
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

959
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
959

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of seaweed extract application under salinity stress on growth characteristics and antioxidant response of ornamental pansy (Viola × wittrockiana).

Scientific reports·2026
Same author

MYO6 and Heart: A Novel Variant in a Deaf Infant With Supraventricular Tachycardia.

Molecular genetics & genomic medicine·2026
Same author

MECP2 Variant Spectrum and Genotype-Phenotype Correlations in Iranian Rett Syndrome Patients: Identification of a Novel Frameshift Mutation.

Journal of molecular neuroscience : MN·2026
Same author

Group-Based Advance Care Planning for Parkinson's Spectrum Disorders: A Retrospective Evaluation of an Integrated Outpatient Model.

The American journal of hospice & palliative care·2026
Same author

From gene to heart: the impact of a novel SGCD variant in familial dilated cardiomyopathy.

BMC medical genomics·2026
Same author

Genetic and clinical insights into pontocerebellar hypoplasia: Identification of novel variants in an Iranian cohort.

European journal of medical genetics·2026

Related Experiment Video

Updated: Feb 20, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.9K

Next generation sequencing applications for cardiovascular disease.

Samira Kalayinia1, Hamidreza Goodarzynejad2, Majid Maleki1

  • 1a Cardiogenetic Research Laboratory , Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences , Tehran , Iran.

Annals of Medicine
|October 14, 2017
PubMed
Summary

Next-generation sequencing (NGS) offers faster, cheaper genome analysis than traditional methods. This technology is revolutionizing the detection of genetic variations in cardiovascular diseases (CVDs), aiding in diagnosis and risk profiling.

Keywords:
Cardiomyopathiescardiovascular geneticschannelopathiescomplex diseasecoronary artery diseasenext generation sequencingstroke

More Related Videos

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.3K
Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
11:11

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

17.4K

Related Experiment Videos

Last Updated: Feb 20, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.9K
Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.3K
Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
11:11

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

17.4K

Area of Science:

  • Genomics
  • Cardiovascular Medicine
  • Genetic Diseases

Background:

  • The Human Genome Project (HGP) initially relied on Sanger sequencing, a slow and expensive method.
  • Next-generation sequencing (NGS) dramatically accelerates genome sequencing and reduces costs.
  • NGS enables whole-genome (WGS) and whole-exome sequencing (WES) for genetic variation detection.

Purpose of the Study:

  • To discuss recent applications of NGS in cardiovascular medicine.
  • To explore NGS's role in diagnosing Mendelian and complex cardiovascular diseases.
  • To outline future uses and limitations of NGS in clinical practice for CVDs.

Main Methods:

  • Review of current literature on NGS applications in cardiovascular genetics.
  • Analysis of NGS's utility in identifying genetic variants for Mendelian and complex CVDs.
  • Consideration of both whole-genome and whole-exome sequencing approaches.

Main Results:

  • NGS is effective in identifying novel causative mutations for Mendelian cardiovascular diseases.
  • NGS facilitates unbiased, parallel analysis of numerous genes, advancing understanding of complex CVDs.
  • NGS aids in establishing risk profiles by discovering new genetic variants.

Conclusions:

  • NGS significantly enhances the diagnosis and genetic understanding of cardiovascular diseases.
  • NGS offers a powerful tool for both rare Mendelian and complex cardiovascular conditions.
  • Further integration of NGS into clinical practice promises deeper insights into CVD genetics.