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Related Experiment Video

Updated: Feb 20, 2026

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[Twin pregnancy with complete hydatidiform mole].

I N Voloshchuk1, I V Barinova1, N I Kondrikov1

  • 1Moscow Regional Research Institute of Obstetrics and Gynecology, Ministry of Health of the Moscow Region, Moscow, Russia.

Arkhiv Patologii
|October 14, 2017
PubMed
Summary

This case study highlights a rare twin pregnancy involving complete hydatidiform mole (CHM) and a viable fetus. The patient later developed persistent trophoblastic disease, emphasizing the high complication risks associated with CHM pregnancies.

Keywords:
complete hydatidiform molepersistent gestational trophoblastic diseasetwin pregnancyviable fetus

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Area of Science:

  • Reproductive Medicine
  • Gynecologic Pathology

Background:

  • Complete hydatidiform mole (CHM) co-occurring with a normal placenta and viable fetus is a rare obstetric event, estimated at 1 in 20,000-100,000 pregnancies.
  • This condition presents diagnostic challenges, requiring differentiation from partial hydatidiform mole and placental mesenchymal dysplasia, and is associated with a significant risk of complications, including a 50% rate of persistent trophoblastic disease.

Purpose of the Study:

  • To describe a rare case of twin pregnancy with complete hydatidiform mole (CHM) and a viable fetus.
  • To illustrate the diagnostic confirmation of CHM and the subsequent development of persistent trophoblastic disease.

Main Methods:

  • Morphological examination of placental tissue, including macroscopic and microscopic evaluation.
  • Immunohistochemical analysis to assess p57 expression for diagnostic confirmation of CHM.

Main Results:

  • The pregnancy resulted in spontaneous abortion at 16-17 weeks.
  • Morphological examination revealed a normal fetus and placenta alongside CHM tissue. p57 expression was notably absent in the CHM tissue.
  • The patient was diagnosed with persistent trophoblastic disease two months post-abortion.

Conclusions:

  • The case underscores the rarity and diagnostic complexities of co-occurring CHM with a viable twin pregnancy.
  • It highlights the critical need for accurate diagnosis and vigilant monitoring due to the high risk of persistent trophoblastic disease.