Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.

PLoS biology·2024
Same author

A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma.

Cell reports·2024
Same author

A novel mathematical template for developing fDOM probe fluorescence signal correction models for freshwaters.

Journal of environmental sciences (China)·2024
Same author

Effects of wind-driven current and thermal dynamics in a temperate monomictic reservoir: Implications for manganese transport and treatment in water supply systems.

Journal of environmental management·2024
Same author

A Simple and Scalable Zebrafish Model of Sonic Hedgehog Medulloblastoma.

bioRxiv : the preprint server for biology·2024
Same author

Catching nano: Evaluating the fate and behaviour of nano-TiO<sub>2</sub> in swimming pools through dynamic simulation modelling.

Journal of environmental management·2023
Same journal

Correction to: Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Deletion of CEACAM1 does not affect retinal and choroidal morphology or transcriptome.

Cell and tissue research·2026
Same journal

Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling.

Cell and tissue research·2026
Same journal

Gill ionocytes of the Lake Magadi tilapia (Oreochromis Alcolapia grahami), an extremophilic teleost native to a highly alkaline environment.

Cell and tissue research·2026
Same journal

Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Effects of gestational protein restriction on autophagy dynamics during odontogenesis.

Cell and tissue research·2026
See all related articles

Related Experiment Video

Updated: Feb 20, 2026

Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

3.3K

Zebrafish as a model to study neuroblastoma development.

Mattie J Casey1, Rodney A Stewart2

  • 1Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.

Cell and Tissue Research
|October 14, 2017
PubMed
Summary
This summary is machine-generated.

Neuroblastoma, a pediatric cancer, originates from neural crest cells. Zebrafish models offer insights into its development and potential new therapies for high-risk cases.

Keywords:
CancerDrugNeuroblastomaSympatheticZebrafish

More Related Videos

Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons
08:24

Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons

Published on: April 18, 2017

12.1K
Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response
09:43

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response

Published on: May 17, 2017

12.2K

Related Experiment Videos

Last Updated: Feb 20, 2026

Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

3.3K
Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons
08:24

Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons

Published on: April 18, 2017

12.1K
Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response
09:43

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response

Published on: May 17, 2017

12.2K

Area of Science:

  • Pediatric oncology
  • Developmental biology
  • Cancer genetics

Background:

  • Neuroblastoma is a pediatric solid tumor originating from neural crest progenitor cells.
  • Tumor location correlates with sympathetic nervous system development, commonly in the adrenal medulla or lumbar sympathetic ganglia.
  • This enigmatic tumor exhibits variable behavior, from spontaneous regression to aggressive metastasis and treatment resistance.

Purpose of the Study:

  • To review the contributions of zebrafish research to understanding neuroblastoma pathogenesis.
  • To explore the potential of zebrafish as a model system for identifying novel therapies for high-risk neuroblastoma.

Main Methods:

  • Review of existing literature on neuroblastoma and zebrafish models.
  • Analysis of genomic and molecular data in neuroblastoma patient stratification.
  • Discussion of developmental and cancer biology approaches in animal models.

Main Results:

  • Zebrafish models have advanced the understanding of neuroblastoma development and genetics.
  • Molecular and genomic technologies enable better risk stratification, guiding treatment intensity.
  • Despite advances, high-risk neuroblastoma survival remains poor, with many tumors lacking obvious mutations.

Conclusions:

  • Understanding neuroblastoma requires integrating genomic, developmental, and cancer biology.
  • Zebrafish offer a powerful platform for dissecting neuroblastoma pathogenesis.
  • This model system holds promise for accelerating the discovery of effective therapies for high-risk neuroblastoma.