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Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice
Published on: October 17, 2018
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Generalized pustular psoriasis triggered by Zika virus infection
A E Paniz Mondolfi1,2, M Hernandez Perez3, G Blohm4
1Department of Tropical Medicine and Infectious Diseases, Hospital Internacional Barquisimeto, Barquisimeto, Lara, Venezuela.
Clinical and Experimental Dermatology
|October 14, 2017
Summary
Zika virus (ZIKV) infection may trigger generalized pustular psoriasis. This case study suggests ZIKV could directly stimulate skin inflammation and immune responses, leading to this severe skin condition.
Area of Science:
- Virology
- Dermatology
- Immunology
Background:
- Zika virus (ZIKV) is an arbovirus spreading globally, primarily known for congenital and neurological effects.
- Knowledge regarding ZIKV's impact on human skin remains limited.
- Cutaneous manifestations of ZIKV infection require further investigation.
Observation:
- A 68-year-old woman developed generalized pustular psoriasis following a ZIKV infection.
- The preceding ZIKV infection episode was otherwise uncomplicated.
- This case presents a potential link between ZIKV and a severe dermatological condition.
Findings:
- Experimental data suggest ZIKV can infect keratinocytes.
- ZIKV may stimulate keratinocyte-derived inflammatory mediators.
- A polyfunctional T-cell immune response in the skin might be involved.
Implications:
- ZIKV infection could be a direct trigger for generalized pustular psoriasis.
- This finding broadens the understanding of ZIKV's clinical spectrum.
- Further research is needed to elucidate the mechanisms linking ZIKV and psoriasis development.
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