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Improved DNA markers for efficient analysis of fragile X families
R Heilig1, I Oberlé, B Arveiler
1LGME and INSERM U184, Faculté de Médecine, Strasbourg, France.
Abstract:
We report the characteristics of two new probes that detect BclI RFLPs useful for analysis of fragile X families. With these two probes and a single blot, 34% of women are heterozygous both for the proximal marker DXS105 (closer to the fragile X locus than the factor IX gene) and for the distal markers DXS52 or the factor VIII gene. Combined with the analysis of previously described polymorphic markers, it is possible to have a majority of families fully informative for flanking markers using a limited number of probes and restriction digests.
