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Endoscopic optical coherence tomography with a focus-adjustable probe.

Wenchao Liao, Tianyuan Chen, Chengming Wang

    Optics Letters
    |October 14, 2017
    PubMed
    Summary
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    This study introduces a focus-adjustable endoscopic probe for optical coherence tomography (OCT) that overcomes depth-of-focus limitations. The novel probe achieves high-resolution imaging across a wide range by adjusting focal planes and enabling 360-degree scanning.

    Area of Science:

    • Biomedical Engineering
    • Optical Imaging
    • Medical Devices

    Background:

    • Optical coherence tomography (OCT) is a valuable imaging modality but is limited by a shallow depth of focus.
    • Existing OCT probes often struggle to image targets at varying depths or require multiple acquisitions.
    • Overcoming these limitations is crucial for enhanced visualization in various medical applications.

    Purpose of the Study:

    • To develop and demonstrate a focus-adjustable endoscopic probe for OCT.
    • To overcome the inherent depth-of-focus limitations of OCT systems.
    • To enable high-resolution, wide-range imaging with a single endoscopic probe.

    Main Methods:

    • The probe utilizes a two-way shape-memory-alloy spring for adjustable working distance (over 1.5 mm).

    Related Experiment Videos

  • A custom hollow-core ultrasonic motor facilitates unobstructed 360-degree distal scanning.
  • Image fusion techniques are employed to combine images from different focal planes.

    • Main Results:

    • The probe achieves adjustable focus, overcoming depth-of-focus limitations through image fusion.
    • A large scanning range with high resolution (axial and lateral ~4 μm) and high sensitivity (100.3 dB) is realized.
    • Successful spectral-domain OCT imaging of phantoms and biological tissues was demonstrated.

    Conclusions:

    • The developed focus-adjustable endoscopic OCT probe offers enhanced imaging capabilities.
    • This technology addresses key limitations in current OCT endoscopic imaging.
    • The probe shows significant potential for improved diagnostic and interventional procedures.