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Research on the correlation of urine calcium integrin binding protein-1 and pro-BNP with ischemic heart failure
1Intensive Care Unit, Daqing Oilfield General Hospital, Daqing, Heilongjiang Province, China. Jasmine1975@126.com.
Insights
Urine calcium integrin binding protein-1 (CIB1) and serum precursor N-terminal brain natriuretic peptide (pro-BNP) are elevated in acute ischemic heart failure. Urine CIB1 shows superior diagnostic value for chronic stable ischemic heart failure compared to serum pro-BNP.
Area of Science:
- Cardiology
- Biomarker Discovery
- Heart Failure Research
Background:
- Ischemic heart failure diagnosis relies on clinical assessment and biomarkers.
- Established biomarkers like pro-BNP have limitations in specificity and sensitivity.
- Novel biomarkers are needed for improved diagnosis and management of heart failure.
Purpose of the Study:
- To investigate the correlation between urine CIB1 and serum pro-BNP levels in ischemic heart failure.
- To evaluate the diagnostic performance of urine CIB1 and serum pro-BNP in acute and chronic stable ischemic heart failure.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) for urine CIB1 detection.
- Radioimmunoassay for serum pro-BNP detection.
- Receiver operating characteristic (ROC) curve analysis to assess diagnostic accuracy.
Main Results:
- Urine CIB1 and serum pro-BNP levels were significantly higher in acute ischemic heart failure patients compared to chronic stable patients and healthy controls.
- A positive correlation was observed between urine CIB1 and serum pro-BNP in acute ischemic heart failure.
- Urine CIB1 demonstrated higher diagnostic accuracy (AUC 0.854) than serum pro-BNP (AUC 0.823) for chronic stable ischemic heart failure.
Conclusions:
- Urine CIB1 and serum pro-BNP are significantly correlated in acute ischemic heart failure.
- Urine CIB1 exhibits superior diagnostic value for chronic stable ischemic heart failure compared to serum pro-BNP.
- Further research is warranted to fully elucidate the clinical utility of urine CIB1.
Objective:
To investigate the correlation between the levels of urine calcium integrin binding protein-1 (CIB1) and serum precursor N-terminal brain natriuretic peptide (pro-BNP) and ischemic heart failure.
Patients And Methods:
30 patients diagnosed as acute ischemic heart failure for the first time in our hospital from January to August 2016 were continuously selected as the observation group 1, 30 patients with chronic stable ischemic heart failure as the observation group 2, and 30 healthy volunteers as the control group. Urine CIB1 level was detected via enzyme linked immunosorbent assay (ELISA) and serum pro-BNP level was detected via radioimmunoassay. The linear correlation between the CIB1 and pro-BNP levels in observation group 1 was observed, and the diagnostic value of CIB1 and pro-BNP levels for chronic stable ischemic heart failure were analyzed using the receiver operating characteristic (ROC) curve.
Results:
CIB1 and pro-BNP levels in the observation group 1 were significantly higher than those in the observation group 2. These levels were significantly lower in the control group (p < 0.05). In the observation group 1, CIB1 and pro-BNP levels were positively correlated (p < 0.05). The diagnostic accuracy of CIB1 for chronic stable ischemic heart failure in the observation group 2 (area under the curve, AUC) was 0.854, the sensitivity was 86.6% and the specificity was 82.5%, respectively. The diagnostic accuracy of pro-BNP was 0.823, the sensitivity was 83.5% and the specificity was 85.9%, respectively.
Conclusions:
There is a significant correlation between the urine CIB1 and serum pro-BNP levels in patients with acute ischemic heart failure. In patients with chronic stable ischemic heart failure, the diagnostic value of urine CIB1 outperforms that of serum pro-BNP, which still needs further study.