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Published on: May 22, 2019
Genetic variations in the p11/tPA/BDNF pathway are associated with post stroke depression
Jinfeng Liang1, Yingying Yue1, Haitang Jiang1
1Department of Psychosomatics and Psychiatry, ZhongDa Hospital, Medical School of Southeast University, Nanjing 210009, PR China; Institute of Psychosomatics, Medical School of Southeast University, Nanjing 210009, PR China.
Journal of Affective Disorders
|October 14, 2017
Summary
Genetic variations in the p11/tPA/BDNF pathway, including TrkB gene polymorphisms and interactions between p11, tPA, and BDNF genes, are associated with post-stroke depression (PSD). These findings highlight the pathway's role in PSD mechanisms.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Post-stroke depression (PSD) is a common complication following stroke.
- Brain-Derived Neurotrophic Factor (BDNF) plays a role in neuronal function and may influence PSD.
- Genetic variations in intracellular signaling pathways, such as the p11/tPA/BDNF pathway, could affect BDNF's impact on PSD.
Purpose of the Study:
- To investigate the association between polymorphisms in candidate genes within the p11/tPA/BDNF pathway and PSD in a Chinese population.
- To explore the gene-gene interactions within this pathway and their contribution to PSD risk.
Main Methods:
- Genotyping of 65 single nucleotide polymorphisms (SNPs) in six genes (p11, tPA, PAI-1, BDNF, TrkB, p75NTR) in 254 acute ischemic stroke patients (122 with PSD, 132 without).
- Assessment of depressive symptoms using the 17-item Hamilton Depression Rating Scale.
- Analysis of SNP and haplotype associations using gPLINK software and gene-gene interactions using generalized multifactor dimensionality reduction software.
Main Results:
- TrkB gene polymorphisms and haplotypes were significantly associated with PSD.
- Specific BDNF haplotypes were also significantly correlated with PSD.
- Significant gene-gene interactions were identified between p11, tPA, and BDNF, as well as between BDNF and TrkB, and BDNF and p75NTR, in relation to PSD occurrence.
Conclusions:
- Genetic variations in the TrkB gene, BDNF haplotypes, and gene-gene interactions within the p11/tPA/BDNF pathway are linked to PSD.
- These genetic factors suggest a central role for the p11/tPA/BDNF pathway in the underlying mechanisms of PSD.
