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Nephele: a cloud platform for simplified, standardized and reproducible microbiome data analysis.

Nick Weber1, David Liou1, Jennifer Dommer1

  • 1Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Bioinformatics (Oxford, England)
|October 14, 2017
PubMed
Summary

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Nephele offers a cloud-based platform for microbiome data analysis, simplifying complex computational tasks for researchers. This tool transforms raw data into biological insights, making microbiome research more accessible.

Area of Science:

  • Microbiology
  • Bioinformatics
  • Computational Biology

Background:

  • The study of the microbiome is rapidly expanding, leading to vast datasets and advanced computational tools.
  • Many researchers face challenges with large-scale data analysis due to limited time, training, or infrastructure for command-line tools.

Purpose of the Study:

  • To introduce Nephele, a cloud-based platform designed to streamline microbiome data analysis.
  • To provide researchers with an accessible tool for transforming raw microbiome data into actionable biological insights.

Main Methods:

  • Nephele is a cloud-based platform built on Amazon Web Services.
  • It features standardized analysis pipelines and a user-friendly web interface.
  • The platform integrates common microbiome analysis tools and reference datasets, such as the Human Microbiome Project (HMP) cohort.

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Main Results:

  • Nephele simplifies the process of analyzing large microbiome datasets.
  • It reduces the computational burden on individual researchers and their institutions.
  • The platform facilitates the transformation of raw microbiome data into biological insights.

Conclusions:

  • Nephele democratizes microbiome data analysis by providing an accessible, cloud-based solution.
  • It empowers researchers to gain biological insights from complex microbiome data without extensive computational expertise.
  • The platform supports the growing field of microbiome research by addressing current data analysis challenges.