Related Experiment Video
Updated: Feb 20, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Quantitative deformation analysis differentiates ischaemic and non-ischaemic cardiomyopathy: sub-group analysis of
James R J Foley1, Peter P Swoboda1, Graham J Fent1
1Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds LS2?9JT, UK.
Insights
Heart failure patients show reduced cardiac torsion and strain. Non-ischaemic cardiomyopathy patients have significantly lower left ventricular twist and torsion compared to ischaemic cardiomyopathy patients.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Differentiating between ischaemic cardiomyopathy (ICM) and non-ischaemic cardiomyopathy (NICM) is crucial for patient treatment and prognosis.
- Heart failure (HF) secondary to left ventricular (LV) systolic dysfunction affects numerous patients, necessitating accurate diagnostic methods.
- Cardiovascular magnetic resonance (CMR) with tissue tagging is a gold standard for assessing myocardial strain and torsion.
Purpose of the Study:
- To investigate differences in torsion and strain parameters between patients with ICM and NICM.
- To compare these parameters in HF patients with healthy, age-matched controls.
- To evaluate the utility of CMR in characterizing myocardial mechanics in different cardiomyopathy types.
Main Methods:
- Fifty-three HF patients (31 ICM, 22 NICM) and 25 controls underwent 3.0T CMR.
- Cine imaging and spatial modulation of magnetization (tagging) were utilized.
- Circumferential strain, torsion, and global longitudinal strain were quantitatively analyzed using feature tracking and tagged images.
Main Results:
- HF patients exhibited reduced LV dimensions, lower ejection fraction (LVEF), torsion, twist, and strain parameters compared to controls.
- No significant differences in LV dimensions, LVEF, or strain parameters were found between ICM and NICM groups.
- NICM patients demonstrated significantly lower LV twist (6.0° ± 3.7° vs. 8.8° ± 4.3°, P=0.023) and torsion (5.9° ± 3.5° vs. 8.8° ± 4.7°, P=0.017) compared to ICM patients.
Conclusions:
- Myocardial twist, torsion, and strain are significantly reduced in heart failure patients compared to controls.
- Despite similar volumetric and strain parameters, patients with NICM show significantly lower LV torsion and twist compared to those with ICM.
- These findings highlight distinct mechanical alterations in NICM that may impact diagnosis and management.
Aims:
To test the hypothesis that patients with ischaemic cardiomyopathy (ICM) and non-ischaemic cardiomyopathy (NICM) have different torsion and strain parameters, and compare to healthy, age-matched controls. VINDICATE investigated efficacy of high-dose vitamin D on patients with heart failure (HF) secondary to left ventricular (LV) systolic dysfunction of any aetiology. It is important to differentiate ICM and NICM as treatment and prognosis varies significantly. Cardiovascular magnetic resonance (CMR) reliably determines aetiology of HF and tissue tagging techniques are recognized as the reference standard measures of strain and torsion.
Methods And Results:
Fifty three patients (31 ICM, 22 NICM) from VINDICATE and 25 controls underwent CMR at 3.0T, including cine imaging in multiple planes and tissue tagging by spatial modulation of magnetization. CMR data were analysed blinded, by quantitatively reporting circumferential strain and torsion from tagged images and global longitudinal strain from feature tracking. HF patients had larger ventricles indexed to body surface area, lower left ventricular ejection fraction (LVEF), LV torsion, twist, and strain parameters compared to controls. There were no significant differences between ICM and NICM in age, blood pressure, heart rhythm, or NYHA status. There was no significant difference in LV dimensions, EF, and strain parameters between ICM and NICM. NICM patients had significantly lower LV twist (6.0 ± 3.7° vs. 8.8 ± 4.3°, P = 0.023) and torsion (5.9 ± 3.5° vs. 8.8 ± 4.7°, P = 0.017) compared to ICM.
Conclusion:
Twist, torsion, and strain are reduced in HF patients compared to controls. Torsion and twist are significantly lower in patients with NICM compared to ICM, despite similar volumetric dimensions, circumferential and longitudinal strain parameters, and LVEF.
More Related Videos
07:21Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
Published on: February 12, 2011
12:45Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
01:25Cardiomyopathy I: Introduction and Classification
01:30Cardiomyopathy II: Dilated Cardiomyopathy
01:17Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...