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Related Experiment Videos

LiverWiki: a wiki-based database for human liver.

Tao Chen1, Mansheng Li1, Qiang He2

  • 1Beijing Institute of Life Omics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, 33 Life Science Park Rd, Changping District, Beijing, 102206, China.

BMC Bioinformatics
|October 15, 2017
PubMed
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LiverWiki is a new wiki-based database integrating diverse liver data, including genes, proteins, and diseases. This resource enables the scientific community to easily share and update liver-related biological information.

Area of Science:

  • Biomedical Informatics
  • Genomics
  • Proteomics
  • Metabolomics

Background:

  • Omics technologies generate vast amounts of liver-related data.
  • Existing liver data resources are fragmented and struggle to keep pace with data growth.
  • Integrating diverse liver data is challenging due to the need for sustained human effort.

Purpose of the Study:

  • To create a comprehensive, community-driven database for liver-related biological data.
  • To provide an accessible and searchable resource for researchers.
  • To facilitate the flexible and efficient sharing of new liver discoveries.

Main Methods:

  • Developed LiverWiki, a wiki-based database using MediaWiki.
  • Integrated liver-related genes, homolog genes, gene expressions (microarray and RNA-Seq), proteins, interactions, post-translational modifications, pathways, diseases, metabolites, and literature.
Keywords:
Community-driven sharingHuman liverWiki-based database

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  • Implemented editable tables to support community contributions and data updates.
  • Main Results:

    • LiverWiki contains 141,897 content pages, including extensive data on genes, proteins, gene expression, metabolites, and diseases.
    • The database facilitates searching, browsing, reviewing, and refining liver-related information.
    • Community contributions allow for the integration of newly produced data with existing knowledge.

    Conclusions:

    • LiverWiki serves as a centralized, comprehensive resource for liver-related data.
    • The platform empowers the research community to share and update data flexibly and efficiently.
    • LiverWiki enables rapid dissemination of new discoveries through immediate integration, bypassing traditional curation bottlenecks.