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Updated: Sep 14, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
Published on: July 24, 2019
Function and Dysfunction of Adult Hippocampal Neurogenesis in Regeneration and Disease
Lei Peng1, Michael A Bonaguidi2
1Broad California Institute for Regenerative Medicine (CIRM) Center, University of Southern California Keck School of Medicine, Los Angeles, California; Department of Stem Cell Biology and Regenerative Medicine, Neuroscience Graduate Program, University of Southern California Keck School of Medicine, Los Angeles, California.
Abstract:
The hippocampus is the only known brain region where physiological neurogenesis continues into adulthood across mammalian species and in humans. However, disease and injury can change the level of adult hippocampal neurogenesis, which plays an important role in regulating cognitive and emotional abilities. Alterations in hippocampal neurogenesis can mediate treatment of mental illness or affect the brain's capacity for repair and regeneration. In the present review, we evaluate how adult neurogenesis contributes to the repair and regeneration of hippocampal circuitry in the face of diseases and injuries. We also discuss possible future directions for harnessing adult neurogenesis for therapeutic use.
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