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New aspects of metabolic conjugation of chloramphenicol
J M Wal1, J C Peleran, E Perdu
1Laboratoire des Xénobiotiques, I.N.R.A., Toulouse, France.
Abstract:
New and major chloramphenicol (CP) metabolites have been isolated from the urine of goats administered [3H]CP. The CP-3-sulfoconjugate has been identified formally from its chromatographic behaviour and mass spectrometric analysis, as well as from incubations of CP with liver cytosol, using synthetic CP-conjugate as reference. Only a strong assumption is made of the identity of the CP-3-phosphoconjugate.