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Related Experiment Videos

Right ventricular function during pharmacological and exercise stress testing in horses.

A Decloedt1, D De Clercq1, S Ven1

  • 1Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

Veterinary Journal (London, England : 1997)
|October 17, 2017
PubMed
Summary

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Exercise significantly impacts equine right ventricular function, causing higher pulmonary artery pressure and altered dimensions post-exercise. Pharmacological stress tests do not replicate these exercise-induced cardiovascular adaptations.

Area of Science:

  • Cardiovascular Physiology
  • Equine Exercise Physiology
  • Veterinary Cardiology

Background:

  • Endurance athletes experience disproportionate increases in pulmonary artery pressure during exercise, potentially leading to right ventricular remodeling.
  • Horses, with their extreme cardiovascular adaptations and threefold increase in pulmonary pressures during exercise, serve as a valuable model for studying these effects.

Purpose of the Study:

  • To examine right ventricular (RV) function in horses using both post-exercise and pharmacological stress echocardiography.
  • To compare the cardiovascular responses to treadmill exercise versus atropine-dobutamine infusion in athletic horses.

Main Methods:

  • Ten healthy horses underwent a randomized cross-over study involving treadmill exercise testing and pharmacological stress echocardiography (atropine-dobutamine infusion).
Keywords:
Athlete’s heartCardiac remodellingPulmonary hypertensionTrainingTreadmill

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  • Echocardiographic parameters, including RV dimensions and function (RV fractional area change), were assessed.
  • Systemic blood pressure, heart rate, cardiac output, and serum cardiac troponin I concentrations were measured.

    • Main Results:

    • Systolic pulmonary artery pressure was significantly higher during exercise and immediately post-exercise compared to pharmacological stress.
    • Right ventricular diameters and the RV to left ventricular area ratio increased post-exercise.
    • Right ventricular fractional area change decreased significantly post-exercise, contrasting with an increase during pharmacological stress.

    Conclusions:

    • Pharmacological stress echocardiography does not accurately mimic the cardiovascular effects of exercise in athletic horses.
    • Treadmill exercise induces distinct changes in RV pressure and function not replicated by pharmacological stimulation, making it unsuitable for studying exercise-induced RV adaptations in horses.