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Microvalve controlled multi-functional microfluidic chip for divisional cell co-culture
Rui Li1, Xingjian Zhang1, Xuefei Lv1
1Beijing Key Laboratory of Bioseparation and Bioanalysis, Beijing Institute of Technology, Beijing 100081, China.
Abstract:
Pneumatic micro-valve controlled microfluidic chip provides precise fluidic control for cell manipulation. In this paper, a multi-functional microfluidic chip was designed for three separate experiments: 1. Different cell lines were dispensed and cultured; 2. Three transfected SH-SY5Y cells were introduced and treated with methyl-phenyl-pyridinium (MPP+) as drug delivery mode; 3. Specific protection and interaction were observed among cell co-culture after nerve damage. The outcomes revealed the potential and practicability of our entire multi-functional pneumatic chip system on different cell biology applications.