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Updated: Aug 14, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

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Published on: February 28, 2017

[Therapeutic targeting of Notch signaling in cancer]

Mehdi Brahmi1, Olivia Bally1, Lauriane Eberst1

  • 1Centre Léon-Bérard, département de cancérologie médicale, 28, rue Laennec, 69373 Lyon cedex 08, France.

Bulletin Du Cancer
|October 17, 2017
PubMed

Insights

The Notch pathway is crucial for development and cancer. Targeting it for cancer therapy is complex, requiring further research due to its role in normal tissue homeostasis.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • The Notch pathway is vital for embryonic development and adult tissue maintenance.
  • Notch signaling involves receptor cleavage, releasing the Notch intracytoplasmic domain (NICD) to regulate gene transcription.
  • Aberrant Notch signaling is implicated in various cancers, including leukemia and solid tumors.

Purpose of the Study:

  • To review the role of Notch signaling in cancer.
  • To discuss the therapeutic potential of targeting Notch signaling in oncology.
  • To highlight the challenges in developing Notch-targeted cancer therapies.

Main Methods:

  • Literature review of Notch pathway function in development and cancer.
  • Analysis of current clinical development of Notch inhibitors.
  • Discussion of the complexities of Notch signaling in cancer therapy.

Main Results:

  • Notch pathway alterations are common in various malignancies.
  • Several Notch-targeting drug classes are in clinical trials.
  • The dual role of Notch in cancer and homeostasis complicates therapeutic strategies.

Conclusions:

  • Notch signaling is a significant target for cancer drug development.
  • Clinical development of Notch inhibitors faces challenges due to pathway complexity and essential physiological roles.
  • Further preclinical and clinical studies are necessary for effective Notch-targeted cancer therapy.
Keywords:
CancerGamma-secretase inhibitorInhibiteurs de gamma-secrétaseNotchTargeted therapyThérapies ciblées

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