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Related Experiment Videos

Pain and consciousness.

Luis Garcia-Larrea1, Hélène Bastuji2

  • 1Central Integration of Pain (NeuroPain) Lab - Lyon Neuroscience Research Center, INSERM U1028, CNRS, UMR5292, Universite Claude Bernard, Bron F-69677, France; Neurological Hospital Pain Center (CETD), Hôpital Neurologique, Hospices Civils De Lyon, Bron F-69677, France Lyon, France.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|October 17, 2017
PubMed
Summary

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Pain perception involves dynamic brain networks, not a fixed matrix. Understanding these networks is key to pain processing and consciousness, even in unconscious states.

Area of Science:

  • Neuroscience
  • Pain Research
  • Cognitive Neuroscience

Background:

  • Pain is an aversive experience arising from coordinated brain activity, often termed the 'pain matrix'.
  • This matrix is a fluid system of interacting networks, not a static structure.
  • It includes nociceptive, salience, and cognitive control networks crucial for pain perception and consciousness.

Purpose of the Study:

  • To elucidate the dynamic neural networks underlying pain perception.
  • To model the progression from nociception to conscious pain experience.
  • To explore the impact of pain on unconscious states and potential long-term consequences.

Main Methods:

  • Analysis of intracortical electroencephalography (EEG) responses in humans.
  • Examination of functional connectivity between sensory and high-level brain networks.
Keywords:
AmygdalaConsciousnessEEGEvoked potentialsInsulaPainfMRI

Related Experiment Videos

  • Description of a model for nociceptive processing and consciousness.

    • Main Results:

    • Nociceptive processing initiates in parallel across sensory, motor, and limbic areas.
    • Rapid recruitment of anterior insular and fronto-parietal networks follows, leading to activation of memory-related structures.
    • Increased functional connectivity in the first second post-stimulus is critical for conscious awareness.
    • A sequential model of pain processing from unconscious to conscious states is proposed.

    Conclusions:

    • Conscious pain perception involves a dynamic interplay of sensory, cognitive, and memory networks.
    • The transition from nociception to consciousness is rapid and dependent on network coordination.
    • Even in unconsciousness, pain can leave implicit traces, potentially contributing to anxiety and hyperalgesia.