Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hearing Without Neuroglobin.

Manuela Nowotny1, Lenneke Kiefer1, Daniel Andre2

  • 1Institute of Cell Biology and Neuroscience, Goethe-University, Frankfurt am Main, Germany.

Neuroscience
|October 17, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ancient conservation of androglobin expression reveals its evolutionary link to ciliary processes.

Molecular biology and evolution·2026
Same author

The MYB-related transcription factor MYPOP acts as a selective regulator of cancer cell growth.

Communications biology·2026
Same author

Flupyradifurone impairs the processing of sound signals by the ascending interneurons AN1 and AN2 that convey auditory information to the cricket brain.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2026
Same author

Transcriptomic insights into the immune responses of the lung and muscle of non-healthy harbor porpoises (<i>Phocoena phocoena</i>).

Frontiers in immunology·2026
Same author

Neuronal processing of complex sounds in the prothoracic ganglion of a bushcricket.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2026
Same author

Interplay between evolutionary history, morphological constraints and functional adaptations in the primate cochlea.

Royal Society open science·2025

Neuroglobin (Ngb) plays a minor role in hearing, with Ngb-knockout mice showing only marginal deficits in auditory function and noise-induced hearing loss recovery compared to wild-type mice.

Area of Science:

  • Neuroscience
  • Auditory Science
  • Molecular Biology

Background:

  • Neuroglobin (Ngb), a respiratory protein, is present in auditory pathway neurons.
  • Its specific role in hearing processes remains largely unknown.

Purpose of the Study:

  • To investigate the function of Neuroglobin in auditory processes.
  • To assess the impact of Ngb absence on hearing function and noise-induced damage.

Main Methods:

  • Auditory function was evaluated using distortion-product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABRs).
  • Comparisons were made between wild-type and Ngb-knockout mice.
  • Noise exposure was used to assess hearing recovery and trauma response.

Main Results:

Keywords:
ABRDPOAEefferentsknockout mice

Related Experiment Videos

  • Ngb-knockout mice showed moderate increases in DPOAE thresholds at specific frequencies.
  • The efferent auditory system's response to contralateral noise was diminished in Ngb-knockout mice.
  • While acute noise exposure caused similar threshold shifts in both groups, ABR amplitudes showed a delayed recovery in Ngb-knockout mice post-trauma.

Conclusions:

  • The absence of Neuroglobin results in only marginal hearing deficits.
  • A potential role for Ngb in the efferent auditory system requires further investigation.