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Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

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Pulmonary sequelae and functional limitations in children and adults with bronchopulmonary dysplasia

Daniel T Malleske1, Olena Chorna2, Nathalie L Maitre3

  • 1Division of Neonatology, Nationwide Children's Hospital/The Ohio State University College of Medicine, United States.

Paediatric Respiratory Reviews
|October 17, 2017
PubMed

Insights

Infants born prematurely with bronchopulmonary dysplasia (BPD) experience lifelong lung problems. This review details BPD

Area of Science:

  • Neonatology
  • Pulmonology
  • Pediatric Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting preterm infants.
  • BPD leads to persistent pulmonary and physical functional deficits throughout life.
  • Understanding these long-term consequences is crucial for patient management.

Purpose of the Study:

  • To review the chronic pulmonary impairments and physical functional limitations in individuals with BPD from infancy to adulthood.
  • To identify potential interventions for children and adults with chronic lung disease (CLD) following preterm birth.

Main Methods:

  • Systematic literature review.
  • Synthesis of current research on BPD-related pulmonary sequelae.
  • Analysis of functional limitations and intervention strategies.

Main Results:

  • Preterm infants with BPD exhibit enduring pulmonary issues affecting physical function.
  • These impairments persist from childhood into adulthood.
  • Evidence suggests opportunities for therapeutic interventions exist.

Conclusions:

  • Bronchopulmonary dysplasia results in lifelong pulmonary and physical functional challenges.
  • Interventions are needed to improve outcomes for individuals with CLD post-preterm birth.
  • Further research should focus on optimizing long-term care and rehabilitation strategies.

Keywords:
Bronchopulmonary dysplasiaExercise capacityExercise trainingPhysical functional limitationsPulmonary function testingPulmonary rehabilitationRespiratory constraints

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