New Polymorph Form of Dexamethasone Acetate
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Ronaldo Pedro da Silva1, Mateus Felipe Schuchter Ambrósio2, Luciana Almeida Piovesan3
1Universidade Federal do Rio de Janeiro, Campus de Xerém, Estrada de Xerém, N° 27, Xerém, Duque de Caxias, Rio de Janeiro 25245-390, Brazil; Pontifícia Universidade Católica do Rio de Janeiro, Departamento de Engenharia Industrial, Rua Marquês de São Vicente, 225, Rio de Janeiro, RJ, 22451-900, Brazil.
Abstract:
A new monohydrated polymorph of dexamethasone acetate was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal and polycrystal X-ray diffraction, solid state nuclear magnetic resonance, infrared spectroscopy. A Hirshfeld surface analysis was carried out through self-arrangement cemented by H-bonds observed in this new polymorph. This new polymorph form appeared because of self-arrangement via classical hydrogen bonds around the water molecule.