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New Polymorph Form of Dexamethasone Acetate.
Ronaldo Pedro da Silva1, Mateus Felipe Schuchter Ambrósio2, Luciana Almeida Piovesan3
1Universidade Federal do Rio de Janeiro, Campus de Xerém, Estrada de Xerém, N° 27, Xerém, Duque de Caxias, Rio de Janeiro 25245-390, Brazil; Pontifícia Universidade Católica do Rio de Janeiro, Departamento de Engenharia Industrial, Rua Marquês de São Vicente, 225, Rio de Janeiro, RJ, 22451-900, Brazil.
Journal of Pharmaceutical Sciences
|October 17, 2017
Summary
Researchers crystallized a new monohydrated polymorph of dexamethasone acetate. This form arises from self-arrangement via hydrogen bonds around a water molecule, confirmed by structural and vibrational analyses.
Area of Science:
- Crystallography
- Solid-state chemistry
- Materials science
Background:
- Dexamethasone acetate is a widely used corticosteroid.
- Polymorphism, the ability of a solid material to exist in multiple crystalline forms, can affect drug properties.
- Understanding new polymorphs is crucial for pharmaceutical development.
Purpose of the Study:
- To crystallize and characterize a novel monohydrated polymorph of dexamethasone acetate.
- To elucidate the structural and vibrational properties of this new form.
- To investigate the intermolecular interactions driving the formation of this polymorph.
Main Methods:
- Single crystal X-ray diffraction
- Polycrystal X-ray diffraction
- Solid-state nuclear magnetic resonance (NMR) spectroscopy
- Infrared (IR) spectroscopy
- Hirshfeld surface analysis
Main Results:
- A new monohydrated polymorph of dexamethasone acetate was successfully crystallized.
- Structural and vibrational properties were comprehensively characterized using multiple analytical techniques.
- Hirshfeld surface analysis revealed self-arrangement cemented by hydrogen bonds around the water molecule, explaining the polymorph's formation.
Conclusions:
- The discovery of this new monohydrated polymorph provides new insights into dexamethasone acetate's solid-state behavior.
- The crystal structure is stabilized by classical hydrogen bonds involving water molecules.
- This finding contributes to the understanding of polymorphism in pharmaceutical compounds.