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Systems proteomics approaches to study bacterial pathogens: application to Mycobacterium tuberculosis
Amir Banaei-Esfahani1, Charlotte Nicod1, Ruedi Aebersold2
1Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland; PhD Program in Systems Biology, Life Science Zurich Graduate School, University of Zurich and ETH Zurich, Zurich, Switzerland.
Current Opinion in Microbiology
|October 17, 2017
Summary
Infectious diseases cause millions of deaths yearly. This review explores omic studies, particularly proteomics, for understanding Mycobacterium tuberculosis and other bacterial pathogens
Area of Science:
- Microbiology
- Systems Biology
- Proteomics
Background:
- Infectious diseases remain a major global health threat, causing millions of deaths annually.
- Traditional molecular biology approaches have limitations in fully understanding complex host-pathogen interactions.
- Pathogens utilize intricate molecular systems to disrupt host biochemical processes.
Purpose of the Study:
- To review omic studies, with a focus on proteomics, applied to Mycobacterium tuberculosis.
- To highlight the utility of systems-level approaches in infectious disease research.
- To demonstrate the portability of these methods to other bacterial pathogens.
Main Methods:
- Review of omic studies, emphasizing proteomic techniques.
- Analysis of systems-level approaches for pathogen research.
- Discussion of proteomic applications in Mycobacterium tuberculosis.
Main Results:
- Omic studies, especially proteomics, offer valuable insights into pathogen molecular mechanisms.
- Systems-level approaches are crucial for deciphering complex host-pathogen interactions.
- Proteomic methods applied to Mycobacterium tuberculosis provide a framework for studying other bacteria.
Conclusions:
- Systems-level omic approaches, particularly proteomics, are essential for advancing infectious disease research.
- Understanding Mycobacterium tuberculosis through these methods can inform strategies against tuberculosis.
- The reviewed proteomic techniques are adaptable for investigating a wide range of bacterial pathogens.