Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exercise training response heterogeneity: physiological and molecular insights.

Lauren M Sparks1,2

  • 1Translational Research Institute for Metabolism and Diabetes, Florida Hospital, 301 E Princeton Street, Orlando, FL, 32804, USA. lauren.sparks@flhosp.org.

Diabetologia
|October 17, 2017
PubMed
Summary

Understanding why some individuals don't benefit from exercise is crucial. This study explores metabolic non-response to exercise training using advanced molecular and clinical data to personalize interventions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and Adherence to a Supervised Aerobic Exercise Training Intervention in Night-Shift Hospital Nurses: A Randomized Controlled Trial.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium.

bioRxiv : the preprint server for biology·2026
Same author

A full-length single nuclei transcriptomic atlas of human skeletal muscle insulin resistance.

bioRxiv : the preprint server for biology·2026
Same author

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA).

medRxiv : the preprint server for health sciences·2026
Same author

The long non-coding RNA landscape of endurance exercise training.

Molecular metabolism·2026
Same author

Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC.

bioRxiv : the preprint server for biology·2026

Area of Science:

  • Exercise physiology and metabolism
  • Human molecular responses to physical activity
  • Personalized exercise interventions

Background:

  • While exercise benefits are known, individual non-response is poorly understood.
  • The National Institutes of Health 'Molecular Transducers of Physical Activity in Humans' project investigates diverse physiological and molecular responses to exercise.
  • Understanding exercise non-response is key to optimizing training outcomes.

Purpose of the Study:

  • To investigate the metabolic aspects of exercise non-response in a large cohort.
  • To identify factors contributing to the lack of favorable responses to exercise training.
  • To leverage multi-omics and clinical data to understand exercise metabolism variability.

Main Methods:

  • Analysis of a nationwide, multicentre clinical trial involving supervised aerobic and resistance exercise.
Keywords:
DiabetesEpigeneticsExerciseHeterogeneityHumanMetabolismMuscleResponseReviewTraining

Related Experiment Videos

  • Focus on metabolic outcomes and the definition of 'non-responder' based on a priori specified outcomes.
  • Integration of multi-omics platforms (genomics, epigenomics, lipidomics, metabolomics, proteomics) with deep clinical phenotyping.

    • Main Results:

    • The study focuses on metabolic non-response, differentiating from cardiorespiratory fitness responses.
    • Integrated -omics approaches are proposed to untangle complex factors influencing exercise response.
    • The research highlights the potential for personalized exercise strategies.

    Conclusions:

    • Harnessing combined -omics platforms and deep phenotyping will advance exercise metabolism research.
    • This approach can shift the paradigm towards targeted exercise interventions for maximum benefit.
    • Novel therapeutic strategies for individuals who do not respond to exercise can be identified.