Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The pathogenesis shared between abdominal aortic aneurysms and intracranial aneurysms: a microarray analysis.

Wen Wang1,2,3,4, Hao Li1,3,4, Zheng Zhao5

  • 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Beijing, 100050, China.

Neurosurgical Review
|October 17, 2017
PubMed

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long noncoding RNA LINC00152 is a potential prognostic biomarker in patients with high-grade glioma.

CNS neuroscience & therapeutics·2018
Same author

An immune-related lncRNA signature for patients with anaplastic gliomas.

Journal of neuro-oncology·2017
Same author

Bioinformatic analysis of gene expression and methylation regulation in glioblastoma.

Journal of neuro-oncology·2017
Same author

Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity.

Viruses·2015
Same author

Diffraction in a stratified region of a high numerical aperture Fresnel zone plate: a simple and rigorous integral representation.

Optics express·2015
Same author

Comparative Genetics of Seed Size Traits in Divergent Cereal Lineages Represented by Sorghum (Panicoidae) and Rice (Oryzoidae).

G3 (Bethesda, Md.)·2015
Summary

This study identified 727 common genes involved in abdominal aortic aneurysms (AAAs) and intracranial aneurysms (IAs). These genes highlight shared pathways in vascular smooth muscle contraction and immune responses, offering potential therapeutic targets for both aneurysm types.

Area of Science:

  • Vascular biology
  • Genomics
  • Immunology

Background:

  • Abdominal aortic aneurysms (AAAs) and intracranial saccular aneurysms (IAs) are prevalent vascular diseases.
  • Understanding their shared molecular pathogenesis is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the common genetic and molecular mechanisms underlying both AAAs and IAs.
  • To identify shared differentially expressed genes and key signaling pathways involved in aneurysm development.

Main Methods:

  • Microarray analysis of 12 IA samples and 12 control arteries.
  • Integration of public microarray datasets for AAAs and IAs.
  • Gene Ontology (GO) and pathway enrichment analysis.
  • Protein-protein interaction (PPI) network analysis.
Keywords:
Abdominal aortic aneurysmsGene ontologyIntracranial aneurysmsMicroarrayPathway analysis

Related Experiment Videos

Main Results:

  • Identified 727 common differentially expressed genes between AAAs and IAs (404 upregulated, 323 downregulated).
  • Common genes were significantly enriched in vascular smooth muscle contraction, immune response, and IL-6/chemokine signaling pathways.
  • PPI analysis revealed 35 hub genes, including TNF, IL6, MAPK13, and CCL5, enriched in inflammatory and immune signaling.

Conclusions:

  • Shared molecular pathways, particularly those involving inflammation and vascular smooth muscle function, contribute to the pathogenesis of both AAAs and IAs.
  • Key identified genes and pathways represent potential therapeutic targets for managing both aneurysm types.