Related Experiment Video
Updated: Aug 5, 2026
07:01
Induction and Testing of Hypoxia in Cell Culture
Published on: August 12, 2011
Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity
Weibo Luo1,2, Yingfei Wang3,4
1Department of Pathology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA. Weibo.Luo@UTSouthwestern.edu.
Cellular and Molecular Life Sciences : CMLS
|October 17, 2017
Summary
Hypoxia-inducible factor (HIF) regulates gene expression during low oxygen. Epigenetic regulators are crucial for controlling HIF
Area of Science:
- Molecular Biology
- Cellular Biology
- Genetics
Background:
- Hypoxia-inducible factor (HIF) is a critical transcription factor responding to oxygen levels.
- HIF controls genes vital for physiological and pathological processes in humans.
- Dysregulation of HIF contributes to various human diseases.
Purpose of the Study:
- To review the multifaceted regulation of HIF transcriptional activity.
- To highlight the role of epigenetic regulators in HIF-mediated transactivation.
- To provide a comprehensive overview of epigenetic control over HIF.
Main Methods:
- Literature review of studies on HIF and epigenetic regulation.
- Analysis of molecular mechanisms linking epigenetic modifiers to HIF.
- Synthesis of current understanding of HIF transcriptional control.
Main Results:
- HIF transcriptional activity is modulated through intricate regulatory networks.
- Epigenetic regulators, including writers, readers, and erasers, significantly impact HIF function.
- Specific examples of epigenetic modifications influencing HIF target gene expression are discussed.
Conclusions:
- Epigenetic mechanisms are fundamental to the precise control of HIF transcriptional activity.
- Targeting epigenetic regulators offers potential therapeutic strategies for HIF-related diseases.
- Further research into the interplay between epigenetics and HIF is warranted.
Keywords:
ATP-dependent chromatin remodelerChromatin reprogrammingEpigenetic eraserEpigenetic readerEpigenetic writerGene regulationHypoxia-inducible factorMore Related Videos
Related Concept Videos
02:04Covalently Linked Protein Regulators
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
These groups modify specific amino acids in a protein.
02:36RNA Polymerase II Accessory Proteins
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
02:04Co-activators and Co-repressors
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
02:04Co-activators and Co-repressors
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...