The contribution of the contingent negative variation (CNV) to goal maintenance

The dot pattern expectancy (DPX) task has been strongly recommended as a measure of goal maintenance, which is impaired in schizophrenia patients. The current event-related potential (ERP) study was designed mainly to identify the ERP component that could represent the goal maintenance process of the DPX task as indexed by the error rate of the BX vs. AY (E_BX-AY). We focused our analysis on the cue-phased contingent negative variation (CNV) and found a significant association between the E_BX-AY and the amplitude of the difference wave of cue B vs. cue A (CNV_B-A) (for CP₃, β=-0.262, P=0.001; for CP_Z, β=-0.184, P=0.025; for CP₄, β=-0.201, P=0.015). Lower E_BX-AY (better goal maintenance) was correlated with larger CNV_B-A. Further analysis found a significant association between the error rate of AY condition (E_AY) and the amplitude of CNV_A (for CP₃, β=-0.180, P=0.029; for CP_Z, β=-0.184, P=0.024; for CP₄, β=-0.208, P=0.011) and a significant association between the error rate of BX condition (E_BX) and the amplitude of CNV_B-A (for CP₃, β=-0.198, P=0.016; for CP_Z, β=-0.165, P=0.043; for CP₄, β=-0.151, P=0.066), but not the amplitude of the CNV_B (all P>0.05). All these results together suggested that the cue-phased CNV could be used to represent the goal maintenance process. Future research needs to verify these results with schizophrenia patients.