Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

4.0K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
4.0K
Stem Cell Culture01:17

Stem Cell Culture

6.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.2K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.2K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and validation of a novel pulse optimization and beam control system for conventional and ultra high dose-per-pulse (FLASH) irradiation.

Medical physics·2026
Same author

Nanoengineering conductive soft interfaces for electrogenic cell interactions: a review of materials, fabrication and functionalisation strategies.

Biofabrication·2026
Same author

Corrigendum to "Simultaneous late-gadolinium enhancement and T1 mapping of fibrosis and a novel cell-based combination therapy in hypertensive mice," [Biomed. Pharmacother. 158 (2023) 114069].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Sex-dependent differences in the progression of renal injury and fibrosis following ischemic acute kidney injury.

Clinical science (London, England : 1979)·2026
Same author

Five-year outcomes of a dedicated, multidisciplinary clinic for decompensated cirrhosis.

Internal medicine journal·2026
Same author

Weekly changes in ventilation response for photon and proton lung cancer patients during radiotherapy.

medRxiv : the preprint server for health sciences·2025

Related Experiment Video

Updated: Feb 20, 2026

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

4.1K

Cell-Based Therapies for Tissue Fibrosis.

Rebecca Lim1,2, Sharon D Ricardo3, William Sievert4,5

  • 1The Ritchie Centre, Hudson Institute of Medical Research, ClaytonVIC, Australia.

Frontiers in Pharmacology
|October 17, 2017
PubMed
Summary
This summary is machine-generated.

Tissue fibrosis, a common response to injury, can cause organ damage and mortality. This review explores fibrotic diseases and highlights stem cell therapies as a promising treatment option.

Keywords:
cell therapyfibrosismesenchymal stem cellsprogenitor cellsstem cells and regenerative medicine

More Related Videos

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

15.2K
Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
10:03

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

10.1K

Related Experiment Videos

Last Updated: Feb 20, 2026

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

4.1K
Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

15.2K
Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
10:03

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

10.1K

Area of Science:

  • Medical Research
  • Regenerative Medicine
  • Pathology

Background:

  • Tissue fibrosis is a common pathological process in chronic diseases, often stemming from injury and wound healing.
  • Unregulated fibrogenesis leads to organ damage, increasing morbidity and mortality, particularly in the lungs, kidneys, and liver.
  • Current treatments for end-stage fibrotic diseases are limited, with organ transplantation being a primary option but facing availability and patient candidacy issues.

Purpose of the Study:

  • To explore the natural history, epidemiology, and pathogenesis of fibrotic diseases in the lungs, kidneys, and liver.
  • To provide an overview of current treatment strategies for fibrotic conditions.
  • To focus on the potential of stem or progenitor cell-based therapies for treating fibrotic diseases.

Main Methods:

  • Review of literature on the natural history, epidemiology, and pathogenesis of fibrotic diseases.
  • Analysis of current treatment strategies for lung, kidney, and liver fibrosis.
  • Examination of pre-clinical and early-phase clinical trial data for stem/progenitor cell-based therapies.

Main Results:

  • Fibrotic diseases in vital organs contribute significantly to global mortality.
  • Organ transplantation is a life-saving but limited therapy for end-stage fibrotic conditions.
  • Stem and progenitor cell-based therapies show substantial pre-clinical and early clinical promise.

Conclusions:

  • Fibrotic diseases pose a major global health challenge requiring novel therapeutic approaches.
  • Stem/progenitor cell therapies represent a promising avenue for treating fibrotic conditions, with growing evidence from preclinical and clinical studies.
  • Further research and clinical trials are warranted to fully establish the efficacy and safety of cell-based therapies for fibrotic diseases.