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Related Experiment Video

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A Neuroscientific Approach to the Examination of Concussions in Student-Athletes
11:32

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Published on: December 8, 2014

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Concussion As a Multi-Scale Complex System: An Interdisciplinary Synthesis of Current Knowledge.

Erin S Kenzie1, Elle L Parks1, Erin D Bigler2

  • 1Systems Science Program, Portland State University, Portland, OR, United States.

Frontiers in Neurology
|October 17, 2017
PubMed
Summary

Traumatic brain injury (TBI) is complex, hindering effective treatment development. Systems science offers a new framework to understand concussion heterogeneity and improve patient care.

Keywords:
complexconcussionmodels of injurymulti-scalenetworkssystems sciencetraumatic brain injury

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Area of Science:

  • Systems science applications in biomedical research.
  • Interdisciplinary approaches to complex health issues.

Background:

  • Traumatic brain injury (TBI) is a significant public health concern with persistent impairments after mild injuries.
  • Current diagnostic and prognostic criteria for TBI are insufficient, and clinical trials have consistently failed to yield effective treatments.
  • The heterogeneity of concussion (mild TBI) and interacting factors complicate recovery, impeding research and clinical advancements.

Purpose of the Study:

  • To review current research on TBI and concussion through the lens of systems science.
  • To identify concepts and thinking patterns that hinder TBI research and care.
  • To develop a multi-scale conceptual framework for understanding concussion.

Main Methods:

  • Iterative literature review.
  • Expert interviews.
  • Systems diagramming.
  • Development of a multi-scale conceptual framework.

Main Results:

  • Identified complexity and heterogeneity as key challenges in TBI and concussion research.
  • Proposed a systems science-based approach to address these challenges.
  • Developed a conceptual framework to synthesize knowledge across disciplines.

Conclusions:

  • A systems science perspective is crucial for understanding the complexity of concussion.
  • The developed framework aims to improve research design, classification, and treatment strategies for TBI.
  • Further development of systems models is needed to advance concussion care.