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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

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RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Related Experiment Video

Updated: Feb 20, 2026

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

Long Non-coding RNAs in Hepatitis C Virus-Infected Cells.

Marina Barriocanal¹, Puri Fortes¹

¹Department of Gene Therapy and Hepatology, Navarra Institute for Health Research (IdiSNA), Centro de Investigación Médica Aplicada, University of Navarra, Pamplona, Spain.

Frontiers in Microbiology

|October 17, 2017

Summary

This summary is machine-generated.

Hepatitis C virus (HCV) infection deregulates long non-coding RNAs (lncRNAs) in liver cells. These lncRNAs influence viral replication, immune responses, and liver disease progression, offering potential therapeutic targets.

Keywords:

HCC HCV IFN response antiviral fibrosis liver cirrhosis lncRNAs proviral

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Area of Science:

Hepatology
Virology
Molecular Biology
Immunology

Background:

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, potentially leading to cirrhosis and hepatocellular carcinoma (HCC).
Long non-coding RNAs (lncRNAs) are increasingly recognized as key regulators in cellular processes, including viral infections and disease development.
HCV infection triggers cellular responses, including interferon (IFN) synthesis and signaling, which in turn affect the expression of cellular lncRNAs.

Purpose of the Study:

To investigate the role of deregulated long non-coding RNAs (lncRNAs) in Hepatitis C virus (HCV) infection and associated liver diseases.
To understand how HCV infection and viral replication modulate the expression of cellular lncRNAs.
To explore the potential of lncRNAs as therapeutic targets for HCV infection and liver pathologies.

Main Methods:

Analysis of lncRNA expression profiles in HCV-infected cells.
Investigation of the interplay between viral components, host transcription factors (e.g., MYC, SP1, NRF2, HIF1α), and lncRNA regulation.
Functional studies to determine the proviral or antiviral roles of specific lncRNAs in the context of HCV infection and liver disease.

Main Results:

HCV infection leads to significant deregulation of specific cellular lncRNAs.
Deregulated lncRNAs can act as positive or negative regulators of the interferon (IFN) antiviral response.
Certain lncRNAs are implicated in the pathogenesis of liver cirrhosis and hepatocellular carcinoma (HCC) in the context of HCV infection.

Conclusions:

Long non-coding RNAs (lncRNAs) are critical players in the molecular landscape of Hepatitis C virus (HCV) infection.
Understanding the mechanisms of lncRNA deregulation and function in HCV infection is crucial for developing novel therapeutic strategies.
Targeting specific lncRNAs holds promise for treating HCV-induced liver diseases, including cirrhosis and HCC.