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Microfluidic cell concentrator with a reduced-deviation-flow herringbone structure.

Ji-Chul Hyun1, Jongchan Choi1, Yu-Gyung Jung2

  • 1School of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, South Korea.

Biomicrofluidics
|October 17, 2017
PubMed
Summary
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This study introduces a novel microfluidic cell concentrator using a reduced-deviation-flow herringbone structure. This improved design enhances cell recovery efficiency and concentration factors for various cell types and sizes.

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Cell Biology

Background:

  • Microfluidic devices are crucial for cell analysis.
  • Traditional herringbone structures face limitations in flow deviation and efficiency.
  • Concentrating low-abundance cells requires advanced techniques.

Purpose of the Study:

  • To develop and evaluate a microfluidic cell concentrator with a reduced-deviation-flow herringbone structure.
  • To improve cell recovery efficiency and concentration factors.
  • To assess the device's utility for pre-analytical sample preparation.

Main Methods:

  • Fabrication of a microfluidic chip featuring a novel reduced-deviation-flow herringbone structure.
  • Experimental testing with various particle sizes and Jurkat cells at high flow rates.

Related Experiment Videos

  • Iterative concentration process to achieve higher concentration factors.

    • Main Results:

    • The reduced-deviation-flow herringbone structure decreased flow deviation by 3.3 times.
    • Achieved 98.5% recovery efficiency and 3.4× concentration factor at 100 ml/h.
    • Iterative concentration yielded >98% recovery and 10-11× concentration factor for specific cells.
    • Maintained cell viability above 96% post-concentration.

    Conclusions:

    • The novel microfluidic concentrator significantly enhances cell concentration performance.
    • The device is effective for concentrating low-abundance cells for downstream analysis.
    • This technology holds promise for improving cell-based research and diagnostics.