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Related Experiment Video

Updated: Feb 20, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
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Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

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3D diffusion-weighted 129 Xe MRI for whole lung morphometry.

Ho-Fung Chan1, Neil J Stewart1, Graham Norquay1

  • 1POLARIS, Academic Unit of Radiology, University of Sheffield, Sheffield, UK.

Magnetic Resonance in Medicine
|October 17, 2017
PubMed
Summary

Hyperpolarized 129Xe MRI provides a viable alternative to 3He for whole lung morphometry. This technique achieves good agreement with 3He measurements for lung structure mapping.

Keywords:
compressed sensinghyperpolarized 129Xehyperpolarized 3Helung morphometrystretched exponential model

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Area of Science:

  • Pulmonary Medicine
  • Medical Imaging
  • Radiology

Background:

  • Quantitative lung morphometry is crucial for understanding respiratory diseases.
  • Traditional methods using Helium-3 (3He) MRI have limitations.
  • Developing alternatives for lung imaging is an active area of research.

Purpose of the Study:

  • To obtain whole lung morphometry measurements using 129Xenon (129Xe) in a single breath-hold.
  • To optimize 129Xe diffusion-weighted MRI (DW-MRI) parameters for accurate morphometry.
  • To assess 129Xe DW-MRI as an alternative to 3He for lung imaging.

Main Methods:

  • Acquired prospectively undersampled 3D multiple b-value 129Xe DW-MRI datasets.
  • Iteratively optimized diffusion time (Δ) for 129Xe to match 3He diffusive length scale (LmD) estimates from the stretched exponential model (SEM).
  • Benchmarked empirically optimized 129Xe DW-MRI against 3He measurements in healthy volunteers and patients with COPD using SEM and cylinder model (CM).

Main Results:

  • Achieved good agreement between 129Xe and 3He derived LmD (2.2% mean difference) and Lm (1.1% mean difference).
  • Empirically optimized 129Xe diffusion time was 8.5 ms.
  • Compressed sensing enabled single-breath 3D multiple b-value 129Xe DW-MRI acquisition.

Conclusions:

  • 129Xe DW-MRI with optimized parameters is a viable alternative to 3He for whole lung morphometry.
  • SEM and CM provide reliable lung morphometry metrics using 129Xe.
  • Compressed sensing accelerates 129Xe DW-MRI, facilitating clinical application.