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Updated: Feb 20, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation
Michelle L Ratay1, Elena Bellotti2, Riccardo Gottardi3
1Department of Bioengineering, University of Pittsburgh, 427 Benedum Hall 3700 O'Hara Street, Pittsburgh, PA, 15261, USA.
Abstract:
Dry eye disease, age-related macular degeneration, and uveitis are ocular diseases that significantly affect the quality of life of millions of people each year. In these diseases, the action of chemokines, proinflammatory cytokines, and immune cells drives a local inflammatory response that results in ocular tissue damage. Multiple therapeutic strategies are developed to either address the symptoms or abate the underlying cause of these diseases. Herein, the challenges to deliver drugs to the relevant location in the eye for each of these diseases are reviewed along with current and innovative therapeutic approaches that attempt to restore homeostasis within the ocular microenvironment.
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