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Updated: Aug 11, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Decarbethoxylative Arylation Employing Arynes: A Metal-Free Pathway to Arylfluoroamides
Ekta Gupta, Ruchir Kant, Kishor Mohanan1
1Academy of Scientific and Innovative Research , New Delhi 110001, India.
Abstract:
An efficient, metal-free decarbethoxylative arylation protocol for the synthesis of α-aryl-α-fluoroamides from fluoromalonamates, under ambient reaction conditions using aryne as an electrophilic arylating agent, is reported. This decarbethoxylative arylation proceeds under mild conditions and provides a practical and effective entry to a wide range of α-aryl-α-fluoroacetamides. Interestingly, the use of the tert-butyl ester of fluoromalonamate prevented the otherwise rapid decarboxylation step, affording the arylated fluoromalonamate in moderate yield.
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